Highlights

Helps relieve joint pain associated with osteoarthritis
Could be a factor in the maintenance of good cartilage and/or joint health

Description

What is Ultimate Glucosamine?

Ultimate Glucosamine is a powder consisting of 100% pure N-acetylglucosamine. This unique formulation contains no additives, salts, preservatives, colouring agents, gluten, lactose, or yeast. It dissolves readily and can be added to any hot or cold beverage as a mild sweetener.

N-acetylglucosamine is a major component of hyaluronan, a substance that lubricates joints. It is important in the growth, and repair of joint cartilage and joint damage in experimental models of osteoarthritis^1,4.

In addition, it has been shown to have anti-inflammatory properties in vitro. N-acetylglucosamine has been administered to children² in amounts up to 6 grams per day for up to 2 years without any reported adverse effects.

Lack of adverse effects is likely explained by the fact that N-acetylglucosamine is a natural and important nutritional substance. Human breast milk³ contains as much as 1.5 grams per litre of milk and is the second most abundant sugar after lactose.

References

1 Shikhman AR, Amiel D, D’Lima D, Hwang SB, Hu C, Xu A, Hashimoto S, Kobayashi K, Sasho T, Lotz MK. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis. 2005 Jan;64(1):89-94. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1755188/

2 Salvatore S, Heuschkel R, Tomlin S, Davies SE, Edwards S, Walker-Smith JA, French I, Murch SH. A pilot study of N-acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease. Aliment Pharmacol Ther. 2000 Dec;14(12):1567-79. http://www.ncbi.nlm.nih.gov/pubmed/11121904

3 Miller JB, Bull S, Miller J, McVeagh P. The oligosaccharide composition of human milk: temporal and individual variations in monosaccharide components. J Pediatr Gastroenterol Nutr. 1994 Nov;19(4):371-6. www.ncbi.nlm.nih.gov/pubmed/7876988

4 Chang N, Lin YT, Lin CC, et al. The repair of full-thickness articular cartilage defect using intra-articular administration of N-acrtyl-D-glucosamine in the rabbit knee: a randomized controlled trial. BioMed Eng OnLine 2015 14:105. http://www.ncbi.nlm.nih.gov/pubmed/26582033

There are many glucosamine products on the market. Most are irrational combinations without any solid clinical or scientific basis to justify their use. This is not the case for Ultimate Glucosamine.

The Ultimate Difference

https://ultimateglucosamine.ca/ultimate-difference-professionals/

Ingredients & Suggested Use

Suggested Use

Add 1 level teaspoon of Ultimate Glucosamine to any hot or cold drink including tea, coffee, juice, milk, or soda. The once-a-day powder format can easily be adapted to their daily routine:

For a relaxing bedtime drink, add 1 teaspoon to a cup of camomile tea
Add 1 teaspoon to their morning ritual, a smoothie or a cup of coffee
Sprinkle 1 teaspoon over hot or cold cereal

Usual Dose

One Level Teaspoon

Most people take 1 level teaspoon (5 mL), or about 2 grams at a time. Others prefer to use more, especially when they first start taking Ultimate Glucosamine. Since the substance has no known toxicity, 2 to 3 teaspoons per day can be taken without any side effects.

The maximum dosage of N-acetylglucosamine has not been established because it is a food substance.

How long before benefits kick in?

Clinical trials that looked at symptoms of pain and discomfort, the therapeutic response was seen after at least 4 weeks of use. Other studies using this class of medication have shown that the pain relief equivalent to NSAIDs occurs after about 4 to 6 months of use. Trials that looked at harder endpoints, such as joint space narrowing, were much longer. These trials lasted for 3 years.

No Known Interactions

There are no known interactions with prescription medications.